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Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters

Gremmelspacher D, Gawron J, Szczerba BM, Jahn K, Castro-Giner F, Kuipers J, Singer J, Marass F, Gvozdenovic A, Budinjas S, Pueschel HK, Rentsch CA, Zippelius A, Heinzelmann-Schwarz V, Kurzeder C, Weber WP, Rochlitz C, Vetter M, Beerenwinkel N & Aceto N.

Nature Genetics. 2 Jun 2025. PMID: 40457073

Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial

Kurzeder C, Nguyen-Sträuli BD, Krol I, Ring A, Castro-Giner F, Nüesch M, Asawa S, Zhang YW, Budinjas S, Gvozdenovic A, Vogel M, Kohler A, Grašič Kuhar C, Schwab FD, Heinzelmann-Schwarz V, Weber WP, Rochlitz C, Vorburger D, Frauchiger-Heuer H, Witzel I, Wicki A, Kuster GM, Vetter M & Aceto N.

Nature Medicine. 24 Jan 2025. PMID: 39856336

A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells

Zhang YW, Gvozdenovic A and Aceto N.

Cancer Discovery. 5 Apr 2024. PMID: 38581442

Biology, vulnerabilities and clinical applications of circulating tumor cells

Ring A, Nguyen-Sträuli BD, Wicki A and Aceto N.

Nature Reviews Cancer. 9 Dec 2022. PMID: 36494603

The metastatic spread of breast cancer accelerates during sleep

Diamantopoulou Z, Castro-Giner F, Schwab FD, Foerster C, Saini M, Budinjas S, Strittmatter K, Krol I, Seifert B, Heinzelmann-Schwarz V, Kurzeder C, Rochlitz C, Vetter M, Weber WP, & Aceto N.

Nature. 22 Jun 2022. PMID: 35732738

An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression

Scheidmann MC , Castro-Giner F, Strittmatter K, Krol I, Paasinen-Sohns A, Scherrer R, Donato C, Gkountela S, Szczerba BM, Diamantopoulou Z, Muenst S, Vlajnic T, Kunz L, Vetter M, Rochlitz C, Taylor V, Giachino C, Schroeder T, Platt RJ, Aceto N.

Cancer Res. (Cover of the journal). Feb 15 2022. PMID: 34916221

Hypoxia triggers the intravasation of clustered circulating tumor cells

Donato C, Kunz L, Castro-Giner F, Paasinen-Sohns A, Strittmatter K, Szczerba BM, Scherrer R, Di Maggio N, Heusermann W, Biehlmaier O, Beisel C, Vetter M, Rochlitz C, Weber WP, Banfi A, Schroeder T, & Aceto N.

Cell Rep. Sep 8 2020. PMID: 32905777

Neutrophils escort circulating tumor cells to enable cell cycle progression

Szczerba BM, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J, Scheidmann MC, Donato C, Scherrer R, Singer J, Beisel C, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Beerenwinkel N, & Aceto N.

Nature. Feb 6 2019. PMID: 30728496

Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding

Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, Krol I, Scheidmann MC, Beisel C, Stirnimann CU, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, & Aceto N.

Cell. (Cover of the journal). Jan 10 2019. PMID: 30633912

Denosumab treatment is associated with the absence of circulating tumor cells in breast cancer patients

Vetter M, Landin J, Szczerba BM, Castro-Giner F, Gkountela S, Donato C, Krol I, Scherrer R, Balmelli C, Malinovska A, Zippelius A, Kurzeder C, Heinzelmann-Schwarz V, Weber WP, Rochlitz C, & Aceto N.

Breast Cancer Research. Nov 20 2018. PMID: 30458879

Detection of circulating tumor cell clusters in human glioblastoma

Krol I, Castro-Giner F, Maurer M, Gkountela S, Szczerba BM, Scherrer R, Coleman N, Carreira S, Bachmann F, Anderson S, Engelhardt M, Lane H, Evans TRJ, Plummer R, Kristeleit R, Lopez J, & Aceto N.

British Journal of Cancer. Aug 1 2018. PMID: 30065256

A microfluidic device for label-free, physical capture of circulating tumor cell clusters

Sarioglu FA*, Aceto N*, Kojic N, Donaldson MC, Zeinali M, Hamza B, Engstrom A, Zhu H, Sundaresan T, Miyamoto DT, Luo X, Bardia A, Wittner BS, Ramaswamy S, Shioda T, Ting DT, Stott SL, Kapur R, Maheswaran S, Haber DA and Toner M. *Equal contribution.

Nature Methods. 18 May 2015. PMID: 25984697

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis

Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, & Maheswaran S.

Cell. 2014 Aug 28. PMID: 25171411

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz P, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, & Bentires-Alj M.

Nature Medicine. 2012 Mar 4. PMID: 22388088