Selected publications
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Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters
Gremmelspacher D, Gawron J, Szczerba BM, Jahn K, Castro-Giner F, Kuipers J, Singer J, Marass F, Gvozdenovic A, Budinjas S, Pueschel HK, Rentsch CA, Zippelius A, Heinzelmann-Schwarz V, Kurzeder C, Weber WP, Rochlitz C, Vetter M, Beerenwinkel N & Aceto N.
Nature Genetics. 2 Jun 2025. PMID: 40457073
Digoxin for reduction of circulating tumor cell cluster size in metastatic breast cancer: a proof-of-concept trial
Kurzeder C, Nguyen-Sträuli BD, Krol I, Ring A, Castro-Giner F, Nüesch M, Asawa S, Zhang YW, Budinjas S, Gvozdenovic A, Vogel M, Kohler A, Grašič Kuhar C, Schwab FD, Heinzelmann-Schwarz V, Weber WP, Rochlitz C, Vorburger D, Frauchiger-Heuer H, Witzel I, Wicki A, Kuster GM, Vetter M & Aceto N.
Nature Medicine. 24 Jan 2025. PMID: 39856336
A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells
Zhang YW, Gvozdenovic A and Aceto N.
Cancer Discovery. 5 Apr 2024. PMID: 38581442
Biology, vulnerabilities and clinical applications of circulating tumor cells
Ring A, Nguyen-Sträuli BD, Wicki A and Aceto N.
Nature Reviews Cancer. 9 Dec 2022. PMID: 36494603
The metastatic spread of breast cancer accelerates during sleep
Diamantopoulou Z, Castro-Giner F, Schwab FD, Foerster C, Saini M, Budinjas S, Strittmatter K, Krol I, Seifert B, Heinzelmann-Schwarz V, Kurzeder C, Rochlitz C, Vetter M, Weber WP, & Aceto N.
Nature. 22 Jun 2022. PMID: 35732738
An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Scheidmann MC , Castro-Giner F, Strittmatter K, Krol I, Paasinen-Sohns A, Scherrer R, Donato C, Gkountela S, Szczerba BM, Diamantopoulou Z, Muenst S, Vlajnic T, Kunz L, Vetter M, Rochlitz C, Taylor V, Giachino C, Schroeder T, Platt RJ, Aceto N.
Cancer Res. (Cover of the journal). Feb 15 2022. PMID: 34916221
Hypoxia triggers the intravasation of clustered circulating tumor cells
Donato C, Kunz L, Castro-Giner F, Paasinen-Sohns A, Strittmatter K, Szczerba BM, Scherrer R, Di Maggio N, Heusermann W, Biehlmaier O, Beisel C, Vetter M, Rochlitz C, Weber WP, Banfi A, Schroeder T, & Aceto N.
Cell Rep. Sep 8 2020. PMID: 32905777
Neutrophils escort circulating tumor cells to enable cell cycle progression
Szczerba BM, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J, Scheidmann MC, Donato C, Scherrer R, Singer J, Beisel C, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Beerenwinkel N, & Aceto N.
Nature. Feb 6 2019. PMID: 30728496
Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding
Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, Krol I, Scheidmann MC, Beisel C, Stirnimann CU, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, & Aceto N.
Cell. (Cover of the journal). Jan 10 2019. PMID: 30633912
Denosumab treatment is associated with the absence of circulating tumor cells in breast cancer patients
Vetter M, Landin J, Szczerba BM, Castro-Giner F, Gkountela S, Donato C, Krol I, Scherrer R, Balmelli C, Malinovska A, Zippelius A, Kurzeder C, Heinzelmann-Schwarz V, Weber WP, Rochlitz C, & Aceto N.
Breast Cancer Research. Nov 20 2018. PMID: 30458879
Detection of circulating tumor cell clusters in human glioblastoma
Krol I, Castro-Giner F, Maurer M, Gkountela S, Szczerba BM, Scherrer R, Coleman N, Carreira S, Bachmann F, Anderson S, Engelhardt M, Lane H, Evans TRJ, Plummer R, Kristeleit R, Lopez J, & Aceto N.
British Journal of Cancer. Aug 1 2018. PMID: 30065256
A microfluidic device for label-free, physical capture of circulating tumor cell clusters
Sarioglu FA*, Aceto N*, Kojic N, Donaldson MC, Zeinali M, Hamza B, Engstrom A, Zhu H, Sundaresan T, Miyamoto DT, Luo X, Bardia A, Wittner BS, Ramaswamy S, Shioda T, Ting DT, Stott SL, Kapur R, Maheswaran S, Haber DA and Toner M. *Equal contribution.
Nature Methods. 18 May 2015. PMID: 25984697
Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis
Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, & Maheswaran S.
Cell. 2014 Aug 28. PMID: 25171411
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz P, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, & Bentires-Alj M.
Nature Medicine. 2012 Mar 4. PMID: 22388088